Hi there, my dog has been taking simparica trio for two months. I am extremely upset at myself for letting a similar but very serious threat get to my pup again. Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. It is recommended to wash your hands after administering this medication. Is it just me or does it seem like everyone is in this together? Keep the medication in the blister packs provided until ready to use in order to protect from moisture and light. I took her home. I gave my yellow Lab, Sophie, her first Simperica trio. Seizures continue and its Monday. We took him to vet and they gave nausea meds and kept him overnight. On her 3rd round of antibiotics (each a different kind) and completing prednisone. I am so beyond mad, what can I do to get this out of her system and better yet what can we do to get this product off the market. I would absolutely rather be safe than sorry.. no more simparica trio for that guy. I am sorry you are going through this! She seems to have aged five years since T-Day. Now tremors started. Ive read these stories and am also disgusted. I've read that simparica takes 35 days to get out of their system. Simparica may also cause the following side effects: Vomiting Diarrhea Lethargy Contact your veterinarian if your dog experiences any side effects as a result of taking Simparica. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. Not known if there be permanent after-effects. I dont know what to do to get this out of their system?? The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). Mine passed within 24 hours of the first dose. She had the treatment yesterday and seemed ok. I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. The most common side effects of Simparica in dogs are vomiting and diarrhea. We have never had issues with him peeing in the house - EVER, and he peed in my office. The only thing the vet told me was that his ATL liver enzyme levels were just slightly high (170) and it wasn't a concern and we could just do another blood test at his next check-up. They kindly asked that we schedule an immediate check and diagnostic testing at our local vet. They still will not consider that it is the Simparica Trio. 8 months of prednisone and around the clock nursing care at home saved her life. After weekly re-infestations, SIMPARICA TRIO reduced the number of live fleas by 97.8% within 12 hours of infestation for 28 days. How is your puppy doing? 2-6 days in vomiting here and there. If she recovers, cause is the Simparica. I hope these steps will prevent anyone else's pet having to endure this. This is lethal medication for dogs and should be taken off the market now. It is better but not gone. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. He also had a seizure that lasted for about 2 minutes in the middle of the night about 2 months ago and it was the most horrifying thing to watch and feel so helpless. I'm besides myself. Revolution has been around decades with less incidents of animal reactions. Tuesday morning she woke up with horrible diarrhea. It is really eye-opening to see everyone's experiences. Not to worry you, and I hope yours is different outcome! How long did the itching last with your pet. We hope this will solve our problems and he can live a healthy and happy life. FREE shipping and the BEST customer service! 13 March he is also very lethargic and sitll not eating (even his favorite treats). Previously B was on Heartgard and Advantix worked well I guess we switch back. My 11 year old mini Aussie has been taking Simparica 1.5 years. For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. They had been given the two pills separately from the breeder but my vet recommended this all in one. They had no clue what had happened so again we took him to the er and he checked out fine. I too would like to know how long this symptom lasted in other dogs who experienced the same issue. And my 1 year old cockapoo has been having regular seizures and her blood work has come back indicative of liver dysfunction. I want to thank everyone who posted I could not find enough information on other sites. Another one of our dogs also has had several episodes of suddenly crying as if she is in great pain and also began within a week of administering the poison (please don't call this a medicine, it is a poison intended to kill fleas and other bugs and in this case it can also kill your doggie). My 3 other poodles unaffected. Did you ever do an MRI or spinal tap? Coton de Tulear. Maybe? How is ur puppy? Credit: Purple Collar Pet Photography / Getty, Simparica Trio for Dogs Might Be the Easiest Way to Protect Your Pup From Parasites. Sorry to hear about this happening to so many. We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. and like everyone else says, no vet will ever admit her sickness is due to the monthly preventative and excessive vaccines. Two weeks after first simparica dose.parasites gone. He has been drinking more water then usual. He has all the symptoms Eveyone is describing. He is 80% its been 27 days since 2nd dose of Simparico.hoping we turned the corner! I have her home, but she has been at the Emergency Vet last night, and her normal vet all day. So no Addisions. That was when I lived in Fort Lauderdale. We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. Hello! It didnt even occur to me it could be the drug as my doctor just gave individual pills and I didnt get to read side effects. His temp was high and white blood cells elevated. I'm so sorry. My 1 year old Italian Spinone puppy has been losing hair on her back and has a big ear infection. A week ago I gave him Trifexis because he had been on it a few years ago.the next night he had a seizure. He hasn't eaten since and grazes on grass like he is a goat. She has been the healthiest, happiest dog. This behavior is so inconsistent and confusing. And yeah he ate today 4 chicken breast and appeared to want it even better. How long did the itchiness last for your schnauzer? Always confirm storage temperatures by reading the label. Simparica Trio is not effective against adult heartworms. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. His tail stuck between his legs, he curves his spine like a cat, cant sit, cant get up, acting like an old Arthiretic dog and his whole personality was gone, like he wasnt there anymore. Certain age, breed predispositions. 24 hours after, we noticed diarrhea. He had no medical problems before this, and I took him to the vet every year he ended up dying two weeks later , I took him to the vet first they told me he wasnt gonna make it to leave him there and I told him no if he isnt gonna make it, hes going to pass away in my arms at home with me and his family why took him to a different vet not the same one I confronted the woman that gave me that medicine. Strictly natural with zero side effects from now on. around 12 years She grabs and won't let go. I gave my dog his first dose the first week of April. 4.3 4.3 out of 5 stars (34,534) $39.98 $ 39. Is there any good outcomes from this tablet? My Lab mix has had 2 doses of this med. We go for more bloodwork today and are praying for better news. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. After about 35 days he was back to normal. I'm using milk thistle and broccoli sprout powder, and going forward I'm going to use HWF Clean Heart for heartworm prevention. I feel like this drug was pushed by my vet tech and veterinarian. Just gave 3yr old OES first dose yesterday (her half sister got one too) and today she has uncontrolled urination. Im at the 30 day mark from giving him the symparico and he no longer has pain but they want to continue him on a 4-6 months treatment of steroids as if its meningitis but I dont love the idea because the steroids have side effects too. My veterinarian did not warn me of these and now my precious boxer is gone!!!!! Simparico Trio, will not be given to my dog ever again. My 12 yr-old Chihuahua mix is losing his hair right above his nose. I am giving her supplements to support her heart and nerves and she's a little better each day. Was checking out before using . Last year I gave them this but didn't notice any issues. I would notice he gets super tired walking and would go limp in my arms. Coincidence? Can someone please tell me if their dogs got better after taking the pill? Eyes roll back. Although these products can and have been. Will not use this again and will warn others. No way I will ever give it to her again. I was blaming the tremors in his back legs on the fact that he has had both ACLs repaired. The most common Simparica Trio for dogs side effects are; Lethargy Vomiting Diarrhea Loss of appetite Polydipsia Polyuria Hyperactivity Hyperactivity, polydipsia, and polyuria happened in very rare cases. I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. He has horrible water like stools. Vet thought was inner ear infection now thinking otherwise. This past October he just wasn't the same. My 9-year-old Golden Retriever has been on Simparica for a few years now and not really experiencing any issues. She had been on the Seresto collar and Tri-Heart for 8 years with no issues. He is just laying in his crate . I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. She's pacing and wants to eat grass. Also feed bland diet- rice, ground beef, chicken, cottage cheese. Does any one think this could be a reaction to Simparico Trio? Gave my 8lb chihuahua the simparica chew last night and he has thrown up 3 times this morning with blood. CET Enzymatic Oral Hygiene Chews for Dogs. She keeps running through the house as though looking for something. Last month she had diarrhea and it lasted 7 days. So I started searching and came across this blog and my heart just sank. For the next 3-4 days I noticed he would be a bit hesitant to jump or hop around and play as he normally does (and his appetite was lower than usual). Friday early evening Bellas stool was still soft with structure with the outside color almost black but the inside was tinged with lime green. I started thinking about his history. Also what are you looking at giving your dog as a seizure medication?? She had right sided weakness, with right sided neglect( the inability to process stimuli with impaired spatial recognition ). My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. Yes, she was still having seizures! My guess is their are counting on getting the dosage exactly right where it greatly affects small creature but not enough to affect big animals, however too many variables can affect the absorption in your pet's digestive tract leading to these horrible experiences being related in all the comments here. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). Trifexis is much safer and I really don't care about the ticks - I can pull those off. Be aware! My dog has had 3 seizures in the past from wearing a flea collar. If my dog dies, which does not look too good right now for him, I will stop at nothing to make the company's life miserable. Vet says Simparica is not the reason for his condition, but he was totally fine prior to taking Simparica!! He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. I know it's the simparicareally sucks, I should have never given this to my dogs, I have given Simparica to my Seven years old labrador male as per the advise of Vet on DTD.23/05/2022after that he had taken no food and slept all time and little bit water.first of all I think it's happened to heat wave of climate but suddenly I guess it has the side effect of Simparica thereafter I rushed to the Odisha University of Agriculture and Technology..after blood testthe vet. She was shaking like she was freezing. Other adverse reactions like lethargy, anorexia, itching, and increased thirst are possible but not very likely. He wasnt throwing up at all until he received this medication. I am a physical therapist, and acquired Sadie to serve as a Therapy Dog in our clinic. 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