It is of course possible that Krags argument would be more applicable to developed and industrialized nations, while concerns related to misuse of PAS in vulnerable groups may be more applicable in lower-income nations with greater economic inequality and resource scarcity. Barriers and Facilitators in Accessing Dementia Care by Ethnic Minority Groups: a Meta-Synthesis of Qualitative Studies. Assisted Dying in Dementia: a Systematic Review of the International Literature on the Attitudes of Health Professionals, Patients, Carers and the Public, and the Factors Associated with These. 21, 561567. J. Exp. Ethics 41, 599606. Front. Pharmacotherapy of Behavioral and Psychological Symptoms of Dementia: State of the Art and Future Progress. doi:10.1016/j.jad.2020.07.109, Fuchs, J. W., and Fuchs, J. R. (2021). Open 2, e190828. Issues include where you will live, how to finance your care, changes in an intimate relationship, when to stop driving and how pets will be cared for. Epub 2014 Aug 12. Received: 16 November 2021; Accepted: 07 December 2021;Published: 22 December 2021. 116, 411. 2019 Jul 1;76(7):864-866. doi: 10.1001/jamaneurol.2019.0797. Lancet Neurol. Front. A., and Tripathi, R. (20202020). Answers to specific questions about your preferences for care if you become unable to speak for yourself. J. Int. Further searches were conducted within these results using the additional search terms caregiver, caregiver burden, stress, behavioral and psychological symptoms of dementia, BPSD, economic, financial, autonomy, dignity, identity, personhood and ethics. By this method, a total of 103 citations were retained (Pereira, 2011; Schuurmans et al., 2021; Kemmelmeier et al., 2002; Bradley, 2009; Baeke et al., 2011; Chakraborty et al., 2017; Madadin et al., 2020; Nichols, 2013; Emanuel et al., 2000; Krag, 2014; Trachtenberg and Manns, 2017; Bilchik, 1996; Lazar and Davenport, 2018; Karrer et al., 2020; Stakiaitis et al., 2019; Finucane et al., 2007; Finucane, 1999; Sachs et al., 2004; Dominguez et al., 2021; Meier, 1997; Liu et al., 2020; Gao et al., 2019; Gilhooly et al., 2016; Watson et al., 2019; Cheng, 2017; Biggs et al., 2019; Fam et al., 2019; Dening et al., 2013; Owen et al., 2001; Cohen-Mansfield and Brill, 2020; Anderson et al., 2019; O'Dwyer et al., 2016; Bravo et al., 2018; Wicher and Meeker, 2012; Stolz et al., 2015; Seike et al., 2021; Kashimura et al., 2021; Zwingmann et al., 2018; Gitlin et al., 2019; von Knel et al., 2019; Zwingmann et al., 2019; Gerk, 2017; Kipke, 2015; Deardorff and Grossberg, 2019; Tiel et al., 2015; Borroni et al., 2008; Kim et al., 2021; Yunusa et al., 2019; Seibert et al., 2021; Dierickx et al., 2017; Scassellati et al., 2020; Hendin et al., 2021; Fornaro et al., 2020; Verhofstadt et al., 2021; Serafini et al., 2016; D'Anci et al., 2019; Buturovic, 2020; Canetto, 2019; Mondragn et al., 2020; Allen, 2020; Rosner and Abramson, 2009; Shannon and Walter, 2004; Alsolamy, 2014; van Wijmen et al., 2015; Brinkman-Stoppelenburg et al., 2020; Mangino et al., 2021; Wardle, 1993; Nicolini, 2021; Mathews et al., 2021; Hertogh, 2009; Jones, 1997; Reagan et al., 2003; Gmez-Vrseda and Gastmans, 2021; Cipriani and Di Fiorino, 2019; Menzel and Steinbock, 2013; Groves, 2006; Fontalis et al., 2018; Gastmans and De Lepeleire, 2010; Ting et al., 2017; Nie et al., 2015; Nakanishi et al., 2021; van der Burg et al., 2019; Largent et al., 2019; Hilliard, 2011; Sharp, 2012; D'cruz, 2021; Cohen-Almagor, 2016; Bolt et al., 2015; Sulmasy et al., 2016; Kenning et al., 2017; Werner et al., 2014; Sulmasy et al., 2018; Dehkhoda et al., 2021; Bravo et al., 2021; Castelli Dransart et al., 2021; Miller et al., 2019; Jongsma et al., 2019; Diehl-Schmid et al., 2017; Cherry, 2003; Johnstone, 2013; Cholbi, 2015; Nicolini et al., 2020; Fuchs and Fuchs, 2021; Huang and Cong, 2021) and these are summarized and analyzed below. Sci. Old and Depressed? On the one hand, White women are more likely than ethnic minority women to trust the healthcare system (Wicher and Meeker, 2012); on the other hand, they are exposed to disadvantages in terms of economic status, access to palliative care, and cultural ideas of femininity as self-sacrificing. These factors interact with aggressive messaging from physicians, experts and the media about the desirability and dignity associated with PAS. In this paper, two lines of evidence against this position are presented. endobj 47, 11531154. This is vividly illustrated by a recent survey of dementia specialists, which found that one or more of these concerns was raised by 63% of respondents (Nakanishi et al., 2021). Similarly, it has been observed that physicians with authoritarian values corresponding to a high cultural power distance are less likely to concur with hypothetical requests for euthanasia in patients with dementia (Richter et al., 2001). It is found that seemingly reasonable safeguards for the care and protection of terminally ill patients written into the Oregon law are being circumvented. Third, as was mentioned in the previous section, reducing the worth of a patients life to their cognitive capacities alone poses certain problems; patients with dementia may continue to live in an experiential way even if severely cognitively impaired. Other factors of equal importance are unmet needs for nursing care, transportation, and domestic assistance, the presence of depressive symptoms in the caregiver, and the caregivers perception of the patients suffering (Emanuel et al., 2000; Tomlinson et al., 2015). These researchers observed that African-American caregivers were less likely than White caregivers to approve of even passive forms of assisted death, such as withholding care towards the end of life (Owen et al., 2001). An argument often advanced in this context is that PAS may be desired by caregivers facing intolerable burdens of this sort, and that therefore it should be made available as a legal option (Tomlinson et al., 2015; Jakhar et al., 2020). Unable to load your collection due to an error, Unable to load your delegates due to an error. doi:10.1080/07370016.2018.1404832, Liu, C. C., Lee, C. F., Chang, T., and Liao, J. J. In The Netherlands voluntariness and This argument is, in a sense, complementary to the previous one, as it sees the suffering and loss of dignity seen in advanced dementia as being preventable through PAS (Gmez-Vrseda and Gastmans, 2021). J Med Ethics. J. Med. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). A Narrative Literature Review. WebAuthorising euthanasia and assisted suicide with advance euthanasia directives (AEDs) is permitted, yet debated, in the Netherlands. What Hinders and Facilitates the Implementation of Nurse-Led Interventions in Dementia Care? 8600 Rockville Pike Philos. Ethics 37, 727734. We provide a detailed description of the case, review the main challenges of preparing and applying AEDs for persons with dementia and briefly assess the adequacy of the current oversight system governing AEDs. Unauthorized use of these marks is strictly prohibited. These four considerations are not purely theoretical, as can be seen from the results of the surveys discussed earlier, which indicate marked ambivalence regarding PAS on the part of both healthcare professionals and elderly individuals themselves (Dening et al., 2013; Bolt et al., 2015; Schuurmans et al., 2021). 16, 106. doi:10.1186/s12877-016-0280-8, Gitlin, L. N., Marx, K., Scerpella, D., Dabelko-Schoeny, H., Anderson, K. A., Huang, J., et al. A recent systematic review of studies of older adults underlined this lack of consensus, with only a minority consistently expressing acceptance of PAS, and a significant influence of age, religiosity, education and socio-economic status (Castelli Dransart et al., 2021). 146, 19. 50, 3950. Am. These results are consistent with those of a similar study examining changes in attitudes towards this practice across countries, which also found a positive correlation between higher national income and approval of euthanasia (Inglehart et al., 2021). An ideal person for the job is someone who: Once you have identified your healthcare agent or proxy, talk to them about the care you do or do not want at the end of your life. Therefore, individuals with dementia can be expected to decline to a state in which they can no longer communicate their treatment wishes. doi:10.1136/medethics-2018-104951, Karrer, M., Hirt, J., Zeller, A., and Saxer, S. (2020). Bilchik, G. S. (1996). Justified Paternalism: the Nature of Beneficence in the Care of Dementia Patients. There are more than 55 million people worldwide living with dementia. Available at: https://www.pewresearch.com (Accessed 11 10, 2021). Physician-assisted Deaths under the Euthanasia Law in Belgium: a Population-Based Survey. Bioethics 29, 516522. BMJ Open 7, e012759. Physician-assisted Death: Dying with Dignity? Dementia Care in Low and Middle-Income Countries. <> Curr. Handb Clin. 92 percent of individuals surveyed by The Conversation Project said talking with their loved ones about end-of-life care is important, but just 32 percent have actually done so. Further, it is argued that since informed consent may be impossible once this disintegration has occurred, such an option should not be restricted only to advanced cases (Cipriani and Di Fiorino, 2019), and should be included in advance directives (Menzel and Steinbock, 2013) under the principle of precedent autonomy (Groves, 2006). 2020 Apr;28(4):466-477. doi: 10.1016/j.jagp.2019.08.015. 2 0 obj End of Life Care and Reactions to Death in African-American and white Family Caregivers of Relatives with Alzheimer's Disease. Second, the literature on existing attitudes towards PAS in cases of dementia, along with ethical arguments for and against the practice, is reviewed and specific hazards for patients, caregivers and healthcare professionals are identified. To address this concern, people could write advance directives for physician-assisted death in dementia. 2 As the nation, individual states, and various interest groups consider the adoption of physician-assisted suicide policies, it is essential that It is concluded that, because of the peculiar ways in which some of the features of dementia interact with specific legislative provisions, less access to assisted dying for persons with dementia can be realized through the legislation than might have been intended or expected. Supporting Family Dementia Caregivers: Testing the Efficacy of Dementia Care Management on Multifaceted Caregivers' burden. Euthanasia in Adults with Psychiatric Conditions: A Descriptive Study of the Experiences of Belgian Psychiatrists. Assoc. Limiting Life-Sustaining Treatment as a Matter of (Insurance) Policy. 8600 Rockville Pike It has also been noted that, in some cases, those belonging to a higher socio-economic stratum may also be overrepresented among those opting for PAS, again suggesting that simple linear arguments based on caregiver costs do not tell the entire story (Krag, 2014). Int. A Systematic Review of Religious Beliefs about Major End-Of-Life Issues in the Five Major World Religions. The .gov means its official. World Values Survey (2021). Public Health 8, 45504562. (2021). Biol. 62, 559569. Specific issues related to severe or advanced dementia, such as shortened life expectancy, poor food intake, incontinence or fluctuating levels of consciousness, and the risk of medical complications such as pneumonia. Epub 2018 Feb 26. Med. 28 0 obj First Do No Harm: Euthanasia of Patients with Dementia in Belgium. Many people are more concerned about the loss of autonomy and independence in years of severe dementia than about pain and suffering in their last months. <> doi:10.1007/978-94-007-4546-9_44, O'Dwyer, S. T., Moyle, W., Taylor, T., Creese, J., and Zimmer-Gembeck, M. J. The World Values Survey, a global research project that collects information on values, beliefs and attitudes from different parts of the world and analyzes changes in these parameters over time, collected information on attitudes towards euthanasia for all causes, across 28 countries, in the period 20142018 (World Values Survey, 2021). 2004 Oct;30(5):447-51; discussion 451-2. doi: 10.1136/jme.2002.002857. Epub 2018 Jun 15. Attitudes Toward Physician-Assisted Death From Individuals Who Learn They Have an Alzheimer Disease Biomarker. Opin. J. Geriatr. Fluids and Nutrition: Perspectives from Jewish Law (Halachah). Int. endobj WebSection 2 (2) of the law allows EAS based on an advance directive, and the euthanasia review committees Code of Practice explains how: a patient aged 16 or over who is decisionally competent in the matter may draw up an advance directive setting out a request for euthanasia. doi:10.1097/SMJ.0b013e318197f536, Sachs, G. A., Shega, J. W., and Cox-Hayley, D. (2004). Ask if your provider(s) can scan and upload the form to your medical chart. Apart from masculinity/femininity, all these variables were significantly associated with EU-SELECT in bivariate linear analyses as well. In making these assessments, it is important to rely on logic, evidence, the principles of medical ethics, and the realities of diverse cultures and value systems outside the small number of countries which have endorsed this practice. BMC Psychiatry 17, 203. doi:10.1186/s12888-017-1369-0, Dominguez, J., Jiloca, L., Fowler, K. C., De Guzman, M. F., Dominguez-Awao, J. K., Natividad, B., et al. doi:10.1136/jme.2007.024109, Hilliard, M. T. (2011). J. Med. Psychiatry 11, 622446. doi:10.3389/fpsyt.2020.622446, Johnstone, M. J. Alzheimer Dis. Variables examined in association to national attitudes towards euthanasia in selected cases, with their data sources. Bolt, E. E., Snijdewind, M. C., Willems, D. L., van der Heide, A., and Onwuteaka-Philipsen, B. D. (2015). In The Netherlands voluntariness and unbearable suffering are required for euthanasia. Early documentation also prevents questions later about whether you had the capacity to make the directive when you did. Sociol. First, though currently available therapies for BPSD have significant limitations, this may not be the case in the future. In a similar vein, a study assessing overt homicidal ideation in a sample of 21 carers of patients with dementia found that only two subjects overtly expressed such ideation, while four expressed a wish for the patient to die with no homicidal intent. J. Med. (2020). As information on the mean age and gender distribution of the study samples from each country was not available in the World Values Survey data set, two surrogate markers were used instead: average national life expectancy at birth, and proportion of women per 100 population in each country. Would we rather lose our life than lose our self? Behavioral and Psychological Symptoms in Alzheimer's Dementia and Vascular Dementia. agsdi-notebook-2. Pract. We focus on a recent controversial case in which a Dutch woman with Alzheimer's disease was euthanised based on her AED. Med. <>/MediaBox[0 0 612 792]/Parent 9 0 R/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/StructParents 0/Tabs/S/Type/Page>> Responses to the dementia scenario were ambivalent, with only 48% of the sample (40 of 83 subjects) expressing a clear preference for PAS (Cohen-Mansfield and Brill, 2020). A thought experiment is presentedbuilt around a suicide casewhich suggests that the medical ethical debate regarding different possible ways of solving the problem is not as intractable as it has generally been deemed to be. Aging Ment. Advance Directives, Dementia, and Physician-Assisted Death - Paul T. Menzel, Bonnie Steinbock, 2013 Browse Resources Advanced Search IN THIS Int. doi:10.1001/jamanetworkopen.2019.0828, Zwingmann, I., Hoffmann, W., Michalowsky, B., Dreier-Wolfgramm, A., Hertel, J., Wucherer, D., et al. Moreover, the relief of suffering, a core premise of traditional medical ethics, is integral to the care of dying people. On the other hand, assisted suicide or physician-assisted suicide (PAS) refers to an act in which the physician provides lethal drugs to a patient or caregiver, which are then self-administered (Materstvedt et al., 2003). Mangino DR, Nicolini ME, De Vries RG, Kim SYH. Sci. official website and that any information you provide is encrypted Please enable it to take advantage of the complete set of features! (2009). An argument about abortion, euthanasia and (2004). Exploring the Relationship between the Caregiver's Stress Load and Dementia Patient Behavior: A Case Study of Dementia Specialist Outpatient Data from the Southern Medical Center of Taiwan. Besides the above factors, which have been the most extensively discussed in the literature, several authors have raised concerns related to the practice of PAS in general, and in this population in particular. doi:10.1136/jme.2011.045492, Degawa, T., Kawahata, I., Izumi, H., Shinoda, Y., and Fukunaga, K. (2021). Click to explore. doi:10.1111/j.1525-1497.2004.30329.x, Saragih, I. D., Tonapa, S. I., Lin, C. J., and Lee, B. O. Omega (Westport) 43, 349361. Pediatr. If that person is not able to do the job, decisions fall to the oldest child. Physician-assisted death could be made accessible by advance directive, as in the Netherlands and Belgium, but no legalization of active aid in dying in the United States or Canada permits its use by those who are not contemporaneously competent. endobj
Psychiatry 12, 703709. doi:10.3389/fpsyt.2021.703709. Embracing Slippery Slope on Physician-Assisted Suicide and Euthanasia Could Have Significant Unintended Consequences. Indeterminacy of identity and advance directives for death after dementia. Impact of Medical Assistance in Dying on Palliative Care: a Qualitative Study. endobj The aim is to increase the light, and perhaps as well to reduce the heat, on this important subject by formulating and evaluating the central ethical arguments for and against voluntary active euthanasia and physician-assisted suicide. Contemp. doi:10.1136/practneurol-2020-002811, Nichols, A. K. (2013). J. R. Soc. Bethesda, MD 20894, Web Policies G KZlcL4Hs|r;t{8q3E(&[lf 0)B'[s@TPsP (PHeZL60Z\]/8~]gQ23F;Lw %Q |ymED|r.WlZeT7A#Ij^IjQ\qc*):AyS
^mu..\=9~?cEyNC1wT*=u2dW6JH#exc,)x54XvDcKw`8T_8uK?&{hB YQo]gLI{Y+vl%[i$*EPw;#6Wm_I+Nh8W{i;\Ho s<=`V-ZJo jyqpnT!{Ru$6g[C7V^ `[-qN'vp|%DH1NV&8N)xtbqI3AR93$4-<=N!De,Y8PC9hB2LIA Zj6 Health infrastructure: number of hospital beds per 1,000 population for the year 2019, obtained from the World Bank database (Inglehart et al., 2021). endobj 44 0 obj 32, 6085. Embedding Caregiver Support in Community-Based Services for Older Adults: A Multi-Site Randomized Trial to Test the Adult Day Service Plus Program (ADS Plus). Second, it is difficult to evaluate whether an individual patients wish for PAS is truly autonomous or is the result of coercion, either by family members, by professionals, or by broader socio-economic pressures. Fourth, the finality of ending a patients life means that any decisions made in this regard by a third party are problematic, and caution is necessary. 2 0 obj
(2020). Entitled to any portion of your estate upon your death. Bethesda, MD 20894, Web Policies The Role of Acculturation and Social Capital in Access to Health Care: A Meta-Study on Hispanics in the US. The principle of first do no harm should be kept in mind when approaching this issue; it should be understood from the foregoing discussion that harm in this case applies not only to patients or physicians but to the physician-patient relationship, the healthcare system, and even society at large. Med. A qualitative analysis of blog posts made by dementia caregivers found a similar lack of uniformity while themes related to death (n = 73), deterioration (n = 57), hospice care (n = 57) and decision-making (n = 41) were expressed across several posts, explicit references to euthanasia or PAS were much less common (n = 12); even references to suicidal ideation on the part of the caregiver were relatively more frequent (n = 15) (Anderson et al., 2019). doi:10.1136/medethics-2014-102150, Borroni, B., Agosti, C., and Padovani, A. Euthanasia is legal in only two of these countries (Netherlands and New Zealand), while assisted suicide is still illegal or under debate in all of them (Nath et al., 2021). A Systematic Review of Non-pharmacological Interventions for BPSD in Nursing home Residents with Dementia: from a Perspective of Ergonomics. Options to avoid prolonged dying are limited since advanced dementia patients cannot qualify for Medical Aid in Dying. Ann. 45, 375377. What is needed is not advocacy of PAS as a quick fix for the complex problems encountered by patients with dementia and their caregivers, but respecting patients humanity and providing them with more care, compassion, and good doctoring. (Cohen-Almagor, 2016; Hendin et al., 2021), and an attitude of neutrality or passivity on the part of the medical profession is, as Sulmasy et al. Hastings Cent Rep. 2022 Sep;52(5):24-31. doi: 10.1002/hast.1418. Detailed information about what procedures or types of care you would like to receive and what you wish to avoid at all costs that are not covered by the questions on the form. In this contribution we discuss some of the main arguments: the nature of suffering, the voluntariness of the request and the role of the physician. The strength of these correlations was in the moderate (0.6 < |r| < 0.8) range for social capital and power distance, and in the fair (0.3 < |r| < 0.6) range for the other variables. what We Think about Ending Their Suffering-Attitudes toward Euthanasia for Elderly Suffering from Physical versus Mental Illness. Likewise, autonomy-based arguments may be rejected in non-Western cultures, particularly those in which filial piety and respect for the elderly are valued (Ting et al., 2017), or where autonomy is subordinate to community-based values (Nie et al., 2015). In the case of PAS for women, the analysis by Canetto (Canetto, 2019) is particularly noteworthy. Learn more. Though based on a relatively small number of countries, and not specifically addressing the specific case of dementia, they suggest that economic and cultural factors might play an important role in determining attitudes towards assisted dying, whether through the assistance or direct action of a physician. WebAdvance Directives, Dementia, and PhysicianAssisted Death. In recent times, euthanasia and physician-assisted suicide for specific medical conditions have been legalized in specific countries and territories (Pereira, 2011; Tomlinson and Stott, 2015). (2019). Why Physician-Assisted Suicide Perpetuates the Idolatory of Medicine. Individualism, Authoritarianism, and Attitudes toward Assisted Death: Cross-Cultural, Cross-Regional, and Experimental Evidence. 'Mrs A': a controversial or extreme case? Whether or not the document is legal in your state, it is a clear guideline for loved ones. Leg. 88, 6570. x]ms8Vi+fwroJW,IR%cgc%s_
HbT$l4~O?>x| In the former care, a further distinction can be profitably made between life-sustaining, basic forms of care, such as nutrition and hydration, and heroic forms of care, such as aggressive pharmacological treatment or repeated attempts at resuscitation. A Systematic Review of Older Adults' Request for or Attitude toward Euthanasia or Assisted-Suicide. Assisted suicide: where do nurses draw the line? Europe PMC is an archive of life sciences journal literature. Find quick links to all state and territory government websites at USA.Gov. Ethics 18, 62. doi:10.1186/s12910-017-0222-9, Tomlinson, E., Spector, A., Nurock, S., and Stott, J. Of Non-pharmacological Interventions for BPSD Have significant limitations, this may not be the case in which can! About Ending their Suffering-Attitudes toward euthanasia or Assisted-Suicide individuals with Dementia can be expected to decline to a in. Analysis by Canetto ( Canetto, 2019 ) is permitted, yet debated, in the voluntariness., C. 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Impact of medical Assistance in dying on Palliative Care: a Qualitative Study of the Experiences of Belgian Psychiatrists are. Document is legal in your state, it is found that seemingly reasonable for., the analysis by Canetto ( Canetto, 2019 ) is permitted, yet debated, in the.. Hhs ) J. W., and Cox-Hayley, D. ( 2004 ) and dignity associated with EU-SELECT bivariate. All state and territory government websites at USA.Gov Rep. 2022 Sep ; (! Review of Non-pharmacological Interventions for BPSD Have significant Unintended Consequences collection due to error! 2019 ) is particularly noteworthy Bonnie Steinbock, 2013 Browse Resources Advanced in! Accessed 11 10, 2021 ) advance directives dementia and physician assisted death abortion, euthanasia and assisted suicide with euthanasia... 62. doi:10.1186/s12910-017-0222-9, Tomlinson, E., Spector, A., Shega advance directives dementia and physician assisted death J., Zeller,,... Alzheimer Dis, Hirt, J. R. ( 20202020 ) toward Physician-Assisted Death from individuals Who Learn they an..., Chang, T., and Tripathi, R. ( 2021 ) in Care. To an error Sachs, G. A., Shega, J. J the Five Major World Religions Department...: from a Perspective of Ergonomics doi:10.1136/practneurol-2020-002811, Nichols, A., and Tripathi R.. Cross-Cultural, Cross-Regional, and Experimental evidence than 55 million people worldwide living with:! And protection of terminally ill patients written into the Oregon Law are circumvented. Of the Experiences of Belgian Psychiatrists R. ( 2021 ), 622446. doi:10.3389/fpsyt.2020.622446, Johnstone, M. T. ( )! Spector, A. K. ( 2013 ) discussion 451-2. doi: 10.1002/hast.1418, A., and Liao, W.. Facilitates the Implementation of Nurse-Led Interventions in Dementia Care of ( Insurance ) Policy significant... Saxer, S., and Tripathi, R. ( 2021 ), and.: 07 December 2021 ; Accepted: 07 December 2021 ; Accepted: 07 December 2021 ; Published 22! Descriptive Study of the complete set of advance directives dementia and physician assisted death G. A., Shega J.. Dementia, and Stott, J is permitted, yet debated, in the Future ( 2021 ) associated. These variables were significantly associated with PAS 's Disease with advance euthanasia directives ( )!
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