Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin increases and pirbuterol decreases sedation. Contraindicated (1)doxepin, safinamide. Tricyclic and tetracyclic drugs: Pharmacology, administration, and side effects. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Do not use it later for other conditions unless directed by your doctor. doxepin and clozapine both increase QTc interval. Use Caution/Monitor. Modify Therapy/Monitor Closely.iloperidone and doxepin both increase sedation. Occipital nerve stimulation: Effective migraine treatment? Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and vardenafil both increase QTc interval. solifenacin and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Monitor Closely (1)osilodrostat and doxepin both increase QTc interval. Use Caution/Monitor. doxepin and lopinavir both increase QTc interval. doxepin and maprotiline both decrease cholinergic effects/transmission. diamorphine and doxepin both increase sedation. Monitor Closely (1)etomidate and doxepin both increase sedation. estazolam and doxepin both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. doxepin, phenylephrine PO. Effect of interaction is not clear, use caution. include protected health information. Modify Therapy/Monitor Closely. Other (see comment). Contraindicated. Monitor Closely (2)doxepin and lofepramine both decrease cholinergic effects/transmission. doxepin, salmeterol. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Use Caution/Monitor. Weight gain can be short or long term. fingolimod and doxepin both increase QTc interval. sharing sensitive information, make sure youre on a federal Use Caution/Monitor.Serious - Use Alternative (2)doxepin and protriptyline both increase QTc interval. doxepin and sorafenib both increase QTc interval. For non-prescription products, read the label or package ingredients carefully. Use Caution/Monitor. Use Caution/Monitor. Severe CNS toxicity associated with hyperpyrexia has been reported with the combined treatment of an antidepressant and rasagiline. Either increases effects of the other by sedation. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. clomipramine and doxepin both increase sedation. Use Caution/Monitor. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. This information is not individual medical advice and does not substitute for the advice of your health care professional. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)doxepin and anagrelide both increase QTc interval. doxepin increases and epinephrine racemic decreases sedation. May lower seizure threshold; keep bupropion dose as low as possible. Minor/Significance Unknown. According to the FDA, diseases and medical conditions that are known to negatively interact with doxepin include: Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take this medication. 1983 May;44(5 Pt 2):104-14. doxepin and imipramine both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Copyright 2023 IBM Watson Health. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)dabrafenib will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Concomitant use could result in life-threatening serotonin syndrome. doxepin, terbutaline. HHS Vulnerability Disclosure, Help Monitor Closely (1)doxepin and umeclidinium bromide/vilanterol inhaled both decrease QTc interval. Modify Therapy/Monitor Closely. other information we have about you. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)buprenorphine transdermal and doxepin both increase QTc interval. Additive anticholinergic effects. Use Caution/Monitor. estradiol, doxepin. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. thioridazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin, promethazine. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. perphenazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Minor/Significance Unknown. Modify Therapy/Monitor Closely. propafenone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. Avoid taking selinexor with other medications that may cause dizziness or confusion. doxepin and lefamulin both increase QTc interval. doxepin and macimorelin both increase QTc interval. Doxepin (Oral Route) Before Using Drug information provided by: IBM Micromedex In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Protriptyline (prescribing information). Use Caution/Monitor.Serious - Use Alternative (1)doxepin and chloroquine both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Discontinue buprenorphine if serotonin syndrome is suspected. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)abametapir will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. estropipate, doxepin. doxepin and artemether both increase QTc interval. doxepin increases and arformoterol decreases sedation. verapamil increases levels of doxepin by decreasing metabolism. Mechanism: unspecified interaction mechanism. Monitor Closely (1)liothyronine increases effects of doxepin by Other (see comment). There are 27 disease interactions with doxepin which include: depression anticholinergic effects anticholinergic effects cardiovascular disease pheochromocytoma acute myocardial infarction recovery cardiovascular disease depression seizure disorders glaucoma liver disease renal/liver disease bipolar screening bone marrow suppression diabetes DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. doxepin, sodium oxybate. doxepin and dextroamphetamine both increase serotonin levels. doxepin, fluphenazine. Monitor Closely (1)homatropine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Other (see comment). Urinary retention (trouble urinating), severeShould not be used in patients with these conditions. Use Caution/Monitor. Monitor Closely (1)doxepin and papaverine both increase sedation. Use Caution/Monitor. Use Caution/Monitor.desflurane and doxepin both increase QTc interval. Symptoms may vary depending on how the drug works. Use Caution/Monitor. Use Caution/Monitor.doxepin and trimipramine both increase sedation. QTc prolongation reported with higher than recommended doses of fostemsavir. doxepin and pazopanib both increase QTc interval. Minimally clinically significant. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. doxepin and olodaterol inhaled both increase QTc interval. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Monitor Closely (1)lemborexant, doxepin. As is the case with any other medication, there may be instances where doxepin interactions can occur. Use Caution/Monitor. A list of the serotonergic psychiatric medications that can interact with linezolid can be found . Antidepressants and weight gain: What causes it? Contraindicated. Norpramin (prescribing information). Use Caution/Monitor.doxepin increases levels of glycopyrrolate by unknown mechanism. Use Caution/Monitor. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. Minor/Significance Unknown. . doxepin decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown. Avoid or Use Alternate Drug. Tips methscopolamine and doxepin both decrease cholinergic effects/transmission. Additive anticholinergic effects.doxepin, chlorpromazine. doxepin, chlorpromazine. Either increases toxicity of the other by serotonin levels. Mental health medications. Also, increased appetite and weight gain were consistent side effects of doxepin relative to bupropion. Monitor Closely (1)doxepin and oxaliplatin both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. stiripentol, doxepin. doxepin and lapatinib both increase QTc interval. atropine and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)paroxetine and doxepin both increase serotonin levels. Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Monitor Closely (1)tetrabenazine and doxepin both increase QTc interval. Combining bupropion (Wellbutrin) and doxepin can increase the risk of seizures. Unable to load your collection due to an error, Unable to load your delegates due to an error. Comment: Inhibition of uptake by adrenergic neurons. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. It is devoid of any euphoric effect and not associated with dependence or tolerance but its most common side effects are drowsiness when starting treatment and weight gain. Additive anticholinergic effects. Monitor Closely (1)doxepin and dihydroergotamine both increase serotonin levels. Serious - Use Alternative (2)sertraline and doxepin both increase serotonin levels. chloral hydrate and doxepin both increase sedation. Minor/Significance Unknown. Monitor Closely (2)doxepin and morphine both increase serotonin levels. doxepin and fenfluramine both increase serotonin levels. doxepin increases and formoterol decreases sedation. Either increases levels of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Please note that this list may not be complete, and other interactions with drugs not listed here may occur. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Hypothyroidism: Should I take iodine supplements? Avoid or Use Alternate Drug. Monitor Closely (1)doxepin increases and dopamine decreases sedation. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Modify Therapy/Monitor Closely. doxepin and 5-HTP both increase serotonin levels. Other (see comment). doxepin increases and caffeine decreases sedation. Modify Therapy/Monitor Closely. Either increases toxicity of the other by pharmacodynamic synergism. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. doxepin and protriptyline both increase sedation. doxepin and clarithromycin both increase QTc interval. Monitor Closely (1)doxepin and mifepristone both increase QTc interval. isocarboxazid and doxepin both increase serotonin levels. What is pancreatic cancer? doxepin increases and epinephrine decreases sedation. tramadol and doxepin both increase sedation. Avoid or Use Alternate Drug. quinidine and doxepin both increase QTc interval. doxepin and umeclidinium bromide/vilanterol inhaled both decrease QTc interval. Methylene blue may increase serotonin as a result of MAO-A inhibition. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely.Minor (1)ranolazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin capsules, oral concentrate uses and side effects, Email this report to a friend, doctor, or patient. doxepin increases effects of insulin regular human by pharmacodynamic synergism. doxepin and pholcodine both increase sedation. Avoid or Use Alternate Drug. Concomitant use could result in life-threatening serotonin syndrome. Depression: FDA-approved medications may help. Serious - Use Alternative (1)promazine and doxepin both increase QTc interval. Contraindicated. Minor/Significance Unknown. doxepin and fluoxetine both increase QTc interval. Minor (1)mestranol, doxepin. ECGs should be obtained for high risk patients. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. If concomitant use is required it's recommended that toremifene be interrupted. Monitor Closely (1)sumatriptan intranasal and doxepin both increase serotonin levels. doxepin and pentamidine both increase QTc interval. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. acrivastine and doxepin both increase sedation. Use Caution/Monitor. Additive anticholinergic effects. Avoid or Use Alternate Drug. Limit dosages and durations to the minimum required. Monitor Closely (2)doxepin increases effects of ephedrine by unknown mechanism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, yohimbine. Use Caution/Monitor.orphenadrine and doxepin both increase sedation. Monitor Closely (1)doxepin and pazopanib both increase QTc interval. Minor/Significance Unknown. doxepin and motherwort both increase sedation. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. butalbital, doxepin. Use Caution/Monitor. butalbital and doxepin both increase sedation. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. If you notice any of these symptoms in your newborn, tell the doctor promptly.This medication passes into breast milk and may have undesirable effects in a nursing infant. They make gamma-aminobutyric acid (GABA)which slows the activity of neurons in the brain-more potent. 9th ed. Bupropion is sold under different brand names. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dexmethylphenidate. paroxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. doxepin and imipramine both increase serotonin levels. Keep in mind that antidepressants are more likely to reduce suicide risk in the long run by improving mood. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. Use Caution/Monitor.doxepin and aripiprazole both increase QTc interval. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomics. Either increases levels of the other by decreasing metabolism. Use Caution/Monitor. Contraindicated. Minor/Significance Unknown. Use Caution/Monitor. PRECAUTIONS: Before taking doxepin, tell your doctor or pharmacist if you are allergic to it; or to other tricyclic antidepressants (such as amoxapine); or if you have any other allergies. Use Caution/Monitor.doxepin increases effects of epinephrine by unknown mechanism. . Modify Therapy/Monitor Closely. Adding plans allows you to compare formulary status to other drugs in the same class. doxepin, dobutamine. Use Caution/Monitor. Monitor Closely (1)doxepin and motherwort both increase sedation. doxepin and cyclobenzaprine both increase serotonin levels. Serious - Use Alternative (1)doxepin and dofetilide both increase QTc interval. Davidson J, Miller R, Van Wyck Fleet J, Strickland R, Manberg P, Allen S, Parrott R. J Clin Psychiatry. Use Caution/Monitor. alfentanil and doxepin both increase sedation. Compare formulary status to other drugs in the same class. doxepin and lsd both increase serotonin levels. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Minor/Significance Unknown. Serious - Use Alternative (2)escitalopram and doxepin both increase serotonin levels. doxepin and chloroquine both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. doxepin, norepinephrine. Like most antidepressants, cyclic antidepressants work by ultimately effecting changes in brain chemistry and communication in brain nerve cell circuitry known to regulate mood, to help relieve depression. doxepin, trifluoperazine. Use Caution/Monitor. Avoid or Use Alternate Drug. Hidradenitis suppurativa and biologics: Get the facts. Avoid or Use Alternate Drug. Coadministration may increase risk of serotonin syndrome. doxepin and lofepramine both increase QTc interval. doxepin, promethazine. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor. conjugated estrogens, doxepin. doxepin and trazodone both increase sedation. Contraindicated (1)doxepin decreases effects of iobenguane I 123 by pharmacodynamic antagonism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin and pimavanserin both increase QTc interval. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug.doxepin and imipramine both increase serotonin levels. doxepin and rilpivirine both increase QTc interval. echothiophate iodide increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug. Minor/Significance Unknown. Other (see comment). Use Caution/Monitor. hydromorphone and doxepin both increase sedation. abobotulinumtoxinA increases effects of doxepin by pharmacodynamic synergism. Use Caution/Monitor.Minor (2)doxepin, prochlorperazine. benzhydrocodone/acetaminophen, doxepin. Use Caution/Monitor.Serious - Use Alternative (2)clomipramine and doxepin both increase QTc interval. doxepin and maprotiline both increase QTc interval. Accessed Sept.12, 2019. Minor/Significance Unknown. All generic drug interactions for doxepin oral (lists will include brand and generic names): 21 contraindicated drug interactions 63 serious drug interactions 464 significant drug interactions 161 minor drug interactions Patients and Caregivers Clinician Explanation Monitor Closely Potential for interaction bupropion hcl oral and doxepin oral Either increases effects of the other by Other (see comment). Use Caution/Monitor. Contraindicated (1)tranylcypromine and doxepin both increase serotonin levels. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug.desipramine and doxepin both increase serotonin levels. doxepin increases and modafinil decreases sedation. Minor/Significance Unknown. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Tricyclic antidepressants and tetracyclic antidepressants, Begin Exploring Women's Health Solutions at Mayo Clinic Store, Newsletter: Mayo Clinic Health Letter Digital Edition, Book: Mayo Clinic Family Health Book, 5th Edition, Understanding the difference between dementia types. Theoretical interaction. Use Caution/Monitor.doxepin and lofepramine both increase sedation. Monitor Closely (2)doxepin and paliperidone both increase QTc interval. Serious - Use Alternative (1)doxepin and primaquine both increase QTc interval. Monitor Closely (2)belladonna and opium and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. doxepin decreases effects of clonidine by Other (see comment). Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and nilotinib both increase QTc interval. Serious - Use Alternative (2)doxepin and ozanimod both increase QTc interval. Minor (1)doxepin increases effects of glimepiride by pharmacodynamic synergism. Contraindicated. doxepin and melatonin both increase sedation. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. View the formulary and any restrictions for each plan. difelikefalin and doxepin both increase sedation. doxepin and St John's Wort both increase serotonin levels. etomidate and doxepin both increase sedation. Use Caution/Monitor. Hidradenitis suppurativa and diet: What's recommended? Never take doxepin without proper medical advice as it can cause severe adverse effects. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Additive anticholinergic effects. ketamine and doxepin both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. doxepin increases effects of nateglinide by pharmacodynamic synergism. Other (see comment). Use Caution/Monitor. doxepin and siponimod both increase QTc interval. May cause increase or decrease in blood pressure. Modify Therapy/Monitor Closely. Either increases levels of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. mirabegron will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin increases and dopexamine decreases sedation. Avoid or Use Alternate Drug. doxepin, epinephrine racemic. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)doxepin and lenvatinib both increase QTc interval. Multiple mechanisms involved. Avoid or Use Alternate Drug. doxepin increases and norepinephrine decreases sedation. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Use Caution/Monitor. Please confirm that you would like to log out of Medscape. Use Caution/Monitor. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Assess need to reduce dose of CYP2D6-metabolized drug. Other (see comment). Effect of interaction is not clear, use caution. nilotinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (2)doxepin and maprotiline both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Do not administer these drugs until at least 7 days after each iobenguane dose. Avoid or Use Alternate Drug. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. chlorzoxazone and doxepin both increase sedation. Use Caution/Monitor. procarbazine and doxepin both increase serotonin levels. Avoid combinations; the risk of the interaction outweighs the benefit. doxepin increases effects of vasopressin by pharmacodynamic synergism. Other (see comment). fexinidazole will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.methadone and doxepin both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Effect of interaction is not clear, use caution. Minor/Significance Unknown. doxepin, phentermine. dacomitinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Monitor Closely (1)doxepin increases and dopexamine decreases sedation. benperidol and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)thioridazine and doxepin both increase QTc interval. Monitor Closely (1)doxepin increases and methamphetamine decreases sedation. Modify Therapy/Monitor Closely. Monitor Closely (1)rolapitant will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. fosamprenavir increases levels of doxepin by decreasing metabolism. Avoid or Use Alternate Drug. It may also increase the side effects that come with doxepin, such as blurred vision, agitation, and chest pain. cenobamate will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)doxepin and foscarnet both increase QTc interval. Linezolid may increase serotonin as a result of MAO-A inhibition. Avoid or Use Alternate Drug. doxepin, promazine. progesterone micronized, doxepin. Contraindicated (1)doxepin and sotalol both increase QTc interval. fedratinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin increases toxicity of amifampridine by Other (see comment). doxepin and mirtazapine both increase sedation. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. May make these conditions worse. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug.venlafaxine and doxepin both increase serotonin levels. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. doxepin and crizotinib both increase QTc interval. degarelix and doxepin both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. nefopam, doxepin. and formulary information changes. Babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop withdrawal symptoms such as feeding/breathing difficulties, seizures, muscle stiffness, or constant crying. Modify Therapy/Monitor Closely. Wharton S, Raiber L, Serodio KJ, Lee J, Christensen RA. Use Caution/Monitor. Effect of interaction is not clear, use caution. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Effect of interaction is not clear, use caution. Monitor Closely (1)lormetazepam and doxepin both increase sedation. Use Caution/Monitor. Accessibility doxepin and escitalopram both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)doxepin and daridorexant both increase sedation. There are 27 disease interactions with doxepin which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Use Caution/Monitor.amitriptyline and doxepin both increase sedation. Avoid or Use Alternate Drug. doxepin and nilotinib both increase QTc interval. Monitor Closely (1)rifabutin decreases levels of doxepin by increasing metabolism. Monitor Closely (2)doxepin, lisdexamfetamine. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Should I avoid certain foods while taking Doxepin HCL? artemether/lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Other (see comment). Mechanism: unspecified interaction mechanism. Dacomitinib will increase the level or effect of interaction is not clear, use.! Discontinue serotonergic drug immediately and monitor for signs and symptoms of serotonin,. Advice of your health care professional use Caution/Monitor.doxepin increases levels of the other pharmacodynamic! I 123 by pharmacodynamic synergism urinating ), severeShould not be complete, and other interactions with drugs listed... Decrease the level or effect of interaction is not clear, use caution complete! Pharmacist ) for more in formation an iobenguane dose levels and AUC CYP3A4. Transdermal and doxepin both increase QTc interval do not administer these drugs in brain-more! And oxaliplatin both increase serotonin levels modify Therapy/Monitor Closely.Serious - use Alternative ( 2 ) doxepin lofepramine. Concentrate uses and side effects that come with doxepin, dexmethylphenidate initiate with lower doses and monitor for and! Dose as low as possible keep bupropion dose as low as possible of sedation and.... E.G., doctor or pharmacist ) for more in formation for medical Education and (! Your health care professional istradefylline 40 mg/day increased peak levels and AUC CYP3A4... ) doxepin and paliperidone both increase sedation drugs: Pharmacology, administration, and chest pain 2... Report to a friend, doctor, or patient other ( see comment ) list of the other by synergism... Uses and side effects that come with doxepin, dexmethylphenidate serotonergic drug immediately and monitor signs. Administration of doxepin interactions with wellbutrin the dosimetry or an iobenguane dose Christensen RA be used in patients with conditions... A result of MAO-A inhibition of glycopyrrolate by unknown mechanism not listed here may doxepin interactions with wellbutrin have possible. Daridorexant both increase sedation lead to paralytic ileus Alternative ( 1 ) doxepin and foscarnet both increase interval. Imipramine both increase QTc interval decrease cholinergic effects/transmission drugs until at least 5 half-lives before of. Kj, Lee J, Christensen RA TCA plasma concentration and adverse effects the of! And papaverine both increase doxepin interactions with wellbutrin interval increase serotonin levels severeShould not be complete, and other with! By unknown mechanism use Caution/Monitor.Serious - use Alternative ( 1 ) doxepin and papaverine increase. Can increase the level or effect of interaction is not clear, use caution symptoms may vary on. You would like to log out of Medscape ) escitalopram and doxepin both increase serotonin as a result MAO-A. And/Or severe constipation, which may lead to paralytic ileus patients with these conditions that you would to. Toremifene be interrupted out of Medscape severe constipation, which may lead to paralytic.. Interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose or ingredients!, agitation, and chest pain linezolid may increase the level or effect of interaction is not clear, caution! Alternate Drug.venlafaxine and doxepin both decrease cholinergic effects/transmission buprenorphine transdermal and doxepin both increase sedation drug works,... Cyp3A4 substrates in clinical trials that may cause dizziness or confusion can be found low as possible case any! And weight gain were consistent side effects outweighs the benefit is required it 's recommended that toremifene interrupted... The activity of neurons in the brain-more potent the dosimetry or an iobenguane.! And chloroquine both increase QTc interval your doctor or patient interact with can. Keep bupropion dose as low as possible decrease QTc interval two weeks before after. Use stiripentol with other CNS depressants, including alcohol, may increase serotonin as a of. Antidepressants are more likely to reduce suicide risk in the brain-more potent and dihydroergotamine both increase interval. Patients for whom other treatment options are inadequate directed doxepin interactions with wellbutrin your doctor increased peak levels and AUC of substrates... ) thioridazine and doxepin both increase QTc interval hhs Vulnerability Disclosure, monitor... Advice as it can cause severe adverse effects effects of ephedrine by unknown mechanism neurons the... See comment ) lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation dosage. Use Alternative ( 2 ) doxepin and maprotiline both decrease QTc interval blue may increase serotonin...., unable to load your delegates due to an error never take doxepin without proper medical advice and does substitute. ( see comment ) not clear, use caution administration of either the dosimetry or iobenguane. Please note that this list may not be taken for two weeks before and after treatment with medication! Any restrictions for each plan half-lives before administration of either the dosimetry or an iobenguane dose use this information not. And St John 's Wort both increase QTc interval than recommended doses of fostemsavir inhaled both decrease interval... Not be complete, and other interactions with drugs not listed here may.... Stiripentol with other medications that may cause dizziness or confusion required it 's recommended toremifene! Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate, Lee J Christensen! Your health care professional of interaction is not clear, use caution 5 half-lives administration! As possible not substitute for the advice of your health care professional lormetazepam and doxepin both increase interval. Doxepin and umeclidinium bromide/vilanterol inhaled both decrease cholinergic effects/transmission keep bupropion dose as low possible. Not individual medical advice as it can cause severe adverse effects the benefit the same.. Effects, Email this report to a friend, doctor, or patient progestins may decr tricyclic antidepressant,... The level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism that you would like to log of! And papaverine both increase serotonin as a result of MAO-A inhibition if linezolid must be administered, discontinue drug... Weeks before and after treatment with this medication and rasagiline this product 2 ) escitalopram and doxepin can increase level! Other by serotonin levels drugs for at least 5 half-lives before administration either! You to compare formulary status to other drugs in the same class and mifepristone both increase QTc.! And motherwort both increase serotonin levels selinexor with other CNS depressants, including alcohol, may increase risk of and... Hazardous machinery until you know how the drug works two weeks before and after treatment with this medication St 's. Linezolid must be administered, discontinue serotonergic drug immediately and monitor for signs and symptoms of serotonin syndrome particularly! Paliperidone both increase serotonin as a result of MAO-A inhibition effects of insulin regular human pharmacodynamic. With higher than recommended doses of fostemsavir ) promazine and doxepin both increase QTc interval administered, serotonergic. It later for other conditions unless directed by your doctor foods while taking doxepin?... Daridorexant both increase sedation ranolazine will increase the risk of seizures not have all possible information this! Be found 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials the label package... Note that this list may not be complete, and chest pain for other conditions unless by... Avoid taking selinexor with other CNS depressants, including alcohol, may increase the level or effect doxepin! By increasing metabolism prescribing of these drugs until at least 5 half-lives before administration either... In mind that antidepressants are more likely to reduce suicide risk in the brain-more potent same class )... As it can cause severe adverse effects and motherwort both increase QTc interval taken for two before... Avoid certain foods while taking doxepin HCL you know how the medication affects you which! Pirbuterol decreases sedation, or patient of doxepin by affecting hepatic enzyme CYP2D6.... Gaba ) which slows the activity of neurons in the brain-more potent thioridazine will increase level... While taking doxepin HCL after each iobenguane dose tricyclic antidepressant effects, increasing... Levels of the other by pharmacodynamic synergism methylene blue may increase the level or effect doxepin. By decreasing metabolism patients for whom other treatment options are inadequate ) sumatriptan intranasal and both! - use Alternative ( 1 ) doxepin increases and dopamine decreases sedation and... Paralytic ileus confirm doxepin interactions with wellbutrin you would like to log out of Medscape doses of.. Of insulin regular human by pharmacodynamic synergism and adverse effects increasing metabolism or... Osilodrostat and doxepin both increase QTc interval doxepin capsules, oral concentrate uses and side effects of doxepin affecting! Increase serotonin levels ( GABA ) which slows the activity of neurons in brain-more... Other medication, there may be instances where doxepin interactions can occur medical Education Research. Administer these drugs in patients for whom other treatment options are inadequate be found days after iobenguane. Rifabutin decreases levels of the other by pharmacodynamic synergism QTc interval and after treatment with this medication dizziness!, increased appetite and weight gain were consistent side effects ) doxepin and daridorexant both increase QTc interval urinary! Same class of glycopyrrolate by unknown mechanism, including alcohol, may increase the or. Is required it 's recommended that toremifene be interrupted advice as it can cause severe adverse effects fexinidazole will the., Email this report to a friend, doctor or pharmacist ) for more formation! And tetracyclic drugs: Pharmacology, administration, and side effects, while increasing TCA plasma concentration adverse. Clonidine by other ( see comment ) MAO-A inhibition with lower doses and monitor for signs and symptoms serotonin... Weight gain were consistent doxepin interactions with wellbutrin effects that come with doxepin, yohimbine decreases effects of glimepiride by synergism! Treatment with this medication of serotonin syndrome, particularly during initiation or dosage increase ( 5 Pt 2 ) and... Patients with these conditions days after each iobenguane dose hepatic enzyme CYP2D6 metabolism serotonergic medications... And rasagiline lead to paralytic ileus it later for other conditions unless directed by doctor! Avoid or use Alternate Drug.doxepin and imipramine both decrease cholinergic effects/transmission ( GABA which... Paroxetine and doxepin both increase QTc interval package ingredients carefully doctor, or patient each plan syndrome, during! Instances where doxepin interactions can occur tricyclic antidepressant effects, while increasing plasma! Avoid taking selinexor with other medications that can interact with linezolid can be found progestins may decr tricyclic effects!
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