Simparica Trio is a tasty monthly chew that provides protection against the biggest threats facing our dogs; fleas, ticks, intestinal worms and deadly heartw. For dogs who have a case of mange or ear mites, the treatment can involve topical applications of compounds containing (you guessed it) Ivermectin. I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. Waxman and Brooks both recommend it. The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. Great summary! I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). She was obviously in discomfort. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. 5 A dog's reaction to flea bites may vary from sores and inflammation to hair loss. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. Great Treats for Collies (Easy on the GI Tract), This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. I found the same data during my search, but question if this information is skewed, because there is likely a much smaller group of dogs using Credelio. Fleas can lay up to 1300 eggs within 50 days, 4 but Simparica Trio kills them before they can even lay eggs. This can provoke neurological toxicity in MDR1 mutant dogs even at standard dosage, as it is well known for drugs like ivermectin . Isoxazolines like NexGard, Simparica and Bravecto are very important for tick prevention and appear safe to use. You should still keep an eye on your pet when introducing new organic products. Are you also on Instagram, by chance? Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. If youre looking for something that will repel parasites, a product such as K9 Advantix II may make a good alternative. I was using Seresto collars and am on the hunt for something else. I found some good information on the Cyphenothrin in Parastar Plus in this article. Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? Thank you! It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. Im not a veterinarian and would of course recommend that you consult with yours, but I do think that dogs vary individually (just like people) and can react differently to certain medications. And thank you for saying so. The puppies was given Simparica Trio per the vet recommendation and I needed some alternatives prior to next appt. Have you had any issues with Seresto? Tap to zoom. It is also frequently prescribed in combination with Heartgard and other anthelmentics, which it should not be, due to potential negative drug-drug interactions. If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. Advantage Multi is a spot-on treatment that targets heartworm, whipworm, roundworm, hookworm, and adult fleas. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? Fortunately, there is a DNA test that will let you know whether your dog has this mutation. I have a 3 year old and an 11 week old Australian Shepherd. We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. , I use Advecta 3 because it prevents and kills I have been in the dog Bussiness for over 26 years and used to use frontline bit past few years switched because frontline doesnt prevent .I never had a problem with advecta 3 and hope its safe, As this is a Collie blog and I assume the majority of people who read this post have a Collie, Im just hesitant to recommend it since many Collies have issues with sensitive skin even if theyre clear of MDR1. To give Sentinel a boost, I recommend using it in conjunction with a weekly topical spray like Natural Chemistry. PARSIPPANY, N.J. - January 04, 2022 - Zoetis today announced that the U.S. Food and Drug Administration (FDA) has approved a new label indication for Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) for the prevention of Borrelia burgdorferi infections as a direct result of . As long as I remember to apply it at least once weekly, Ive found it to be very effective. Best of luck with your girl! On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. Still, if you live in the city and dont walk your dogs through long grass or woodsy areas, this could be a great choice for you. Additionally, it can also be given to cats and even pregnant or nursing animals. So far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts against. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Este perfect pentru caini! While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. It sounds similar to a couple other natural oil products Ive tried. Thanks. Simparica is not a heartworm preventive whereas Simprica TRIO works as a heartworm control treatment. Seresto was his answer, so I asked how effective it would be on a double-coated breed. The product label does say to apply between the shoulder blades where it cant be licked. If youre concerned that your dogs would be grooming each other or gnawing that area in play, I would consider a product that isnt a spot-on. You might want to look at the information on Nexgard. . His food hadnt changed, so Im nearly certain it was an adverse reaction to the Credelio. I will try to find the article again, I stupidly didnt bookmark it. Please tell me if I am wrong. Flea and Tick Prevention Chewable Pills for Dogs - Revolution Oral Flea Treatment for Pets - Pest Control & Natural Defense - Chewables Small Tablets Made in USA. My dogs are on Sentinel right now and Frontline Gold. Simparica Trio has the same main ingredient as . A couple people claimed that the trick to getting them to work well is to use a slicker brush to part the fur of the mane, to ensure the collar is close to the skin for best effect. That way if a tick does make it past the essential oil barrier and bite, itll die anyway. PRUEBA GRATUITA FUNCIONES. I would probably try something like Advantix II or Frontline Gold before Vectra. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines (-laner medications) I discussed in the article. The topical medicines seem to work best with her, but dont do much to keep the tics at bay. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). We have always used Frontline Plus, but it has recently started causing dandruff on our dog, and it makes his coat greasy. I asked the vet for an alternative and was recommended Seresto collar or Vectra 3D. I chose Frontline Plus for him as it seems to be an older, safer spot-on. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. Thats what Im doing for my most recent Collie. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. Best of luck! (There are other places, but none more affordable that Ive found.) I really do not think there is a safe heart worm medicine out there for a MDR1 collie. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. So no, I probably wouldnt recommend it for the average Shetland Sheepdog. Unacceptable for me) He is MDR1 clear. If you do give Interceptor a try, its best practice to offer it with a meal to help avoid stomach upset. 1 x 5mg tablet for 2.8 to 5.5 pounds. It has the same active ingredients as Seresto (plus one), so a bit stronger. I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! I gave her Simparica 5 weeks ago for the first time. He has Credelio for fleas and ticks but we were on a break from this since it is snow and ice where we live. In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. Excellent research and well written article! If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. Happy to help! Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. Thank you so much for writing this article!!! , Emily, thanks for a very helpful and informative article. The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. Tap to zoom. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. Your comment made me realize I might need to add another paragraph or two about Credelio. In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). We have a almost 10 year old tricolor rough collie, named Hollie. Also, it is not recommended for use with other medications. The benefits of Simparica. Congratulations and good luck with your new dog! It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. There are other risks involving Ivermectin. Heartgard got a bad rap after too many dogs had negative reactions to the medication. My dog has been tested and is mutant/normal (MDR1). These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. Background: The efficacy and safety of a novel isoxazoline compound, sarolaner (Simparica , Zoetis) and spinosad (Comfortis , Elanco) as a positive control were evaluated for the treatment and control of natural flea infestations on dogs in two randomised, blinded, multi-centric clinical trials conducted in 11 veterinary clinics in northeastern and southeastern states of Australia. But if youve been using it with no issues, I see no reason not to keep using it! You can even scatter some on your dogs bed. Sarolaner is an . Prevents: Heartworm, Fleas, Intestinal worms (except tapeworm) Comes as: a meaty chew given once every month (afoxolaner & milbemycin) So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. Some remain safe, others should be avoided. In regard to natural products, Ive used some organic topicals, which Ill list later, that aresomewhat effective as repellents; but unfortunately I do not know of any natural pest control products that actually work as well as chemical-based ones. Dash is MDR1 mutant/normal. So far we are very pleased with the results and would definitely recommend this to all our puppy owners as it is very convenient suitable for MDR1 carrier dogs. Remember she is fixed. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. Hi Emily, do you know if panacure is a safe wormer? Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. I personally used Credelio on Yoshi, my MDR1-heterozygous (mutant/normal) female Collie for over a year with great results and no ill effects. Id like to thank you so very much for this in depth article. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! I plan to switch him over to Trifexis also. Thank you for the reminder! We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! So, I now need a good flea/tick med and would rather not get another pill for her to take. . Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. Their lower cost makes them appealing for those of us living life on a budget, but its worth it to spend just a little more for your canines safety. The emphasis of this article will continue to be on safety, though I have no doubt as to the efficacy of certain pest preventives over others. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. Two dogs were positive for D. immitis antigen but not MF on days 210 and 236. 1,9 And the fact is, dogs love both chews. Microfilaria and adult heartworm antigen testing. Options: 3 flavors. They both have tolerated Bravecto very well.no noticeable side effects. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Im leaning toward Frontline Plus based on what you wrote. ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. Just as another concern, I had two cats die from Advantage Multi. My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. That indicates it is a strong chemical compound, so do watch for skin irritation. I have a unique situation. This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. Thank you for bringing this to my attention! Katie P. 11 days ago. Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses. What do you know about this? It was the amount of ticks Ive been having to remove that lead me to your article! Their treatment for this was nexgard and medicated baths. Thousands of dogs have experienced serious adverse reactions after taking . It targets not only heartworms, but also hookworms, roundworms, and whipworms. I appreciate your help as I was trying to navigate so much conflicting information!! He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. But it doesnt hurt mammals. 1x 20mg tablet for 11.1 to 22 pounds. Children should be kept away from the dog for 2 hours until the liquid has had time to dry, and be sure to wash your hands after application. Best of luck to you and Sugar! Simparica Trio works against the same ticks as Nexgard and also protects your dog from heartworms, hookworms, and roundworms. I hope you get this. Hope this helps! I didnt see the link for the drug compatibility. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. Thank you for the positive feedback. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. I read that you you used this combination with success. Doses used for heartworm prevention are safe to use in these breeds of dogs. If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. This gene specifically codes for P-glycoprotein, which is responsible for transporting certain drugs out of the brain. Mary. My other vet never brought this up when discussing my MAS. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. . Hartz products generally dont seem to get very favorable reviews either. Safety. I have an Aussie mix and desperately needed some info on this. Is this vaccine something youve heard of? Happy to help! However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. We sometimes see a Smooth Collie named Frank at our local dog park, and Ive been pretty impressed with him. Safe in avermectin-sensitive collies and dogs with the MDR1 gene; I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. Still be careful to monitor for skin reaction if you try the Frontline Gold, too. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. For those of you who want proof or a more in-depth explanation of whyIve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. Hi Emily It covers fleas, ticks, and heart worms. 5,10 That's two tasty chews to double your dog's dosing delight each month. Thanks Emily! My question is about Capstar. Simparica Trio is proven to kill 5 species of ticks. . Hi Debbie! FREE delivery Tue, Mar 7. Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. Simparica claims to be safe for dogs or breeds sensitive to MDR1 ( including Collies, Australian Shepherds or Border Collies), stating "Simparica Trio and Simparica is well-tolerated in various breeds of dogs when used as directed, including dogs with deficient multidrug-resistant-protein". Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? I live on a farm that borders a forest, so coyotes/deer etc.. no avoiding ticks. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). Im sincerely grateful!! I opted to supplement Credelio or Frontline with the Natural Chemistry repellent spray, and that seems to work pretty well for us. Thats so sad about your cats I had no idea they could also carry a gene that makes them sensitive to certain medications! I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. The active ingredients in Seresto are entirely different from those in Frontline, however. We are waiting for the results from her test for the MDR1 gene. However, its technically safe so long as it isnt applied past the shoulder blades where your Collie could reach it. ivermectin, selamectin)? I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. - It is easy to administer, with no need for pre-treatment or fasting. Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. Good luck with everything, and please keep me updated on how your pup is doing! Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . Any of the above scenarios can cause real problems due to an unintended overdose. It was fine for both my Collies and Aussie mix, but its also not a combination internal/external parasite prevention and didnt have nearly the reported number of seizures as Bravecto, Nexgard, and Simparica. Oh no! Astfel, produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile este fabricat i depozitat la standarde ridicate. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. My plan is to adopt a senior Border to go with my lazy Roughs. I tried it on both my Collies, for example, and it made them so itchy that I had to give them a bath after a day. Enjoy your girl! (I didnt find the information about the 6 reported seizures until after I had already given it to my dogs and seen no ill effects from it.) How can I prevent my dog from getting ticks? Documented negative reactions were only provoked at higher-than-normal dosages and were comparatively mild, consisting of salivation, ataxia (dilated pupils), and depression. However, it did make my Collies too itchy. I like Frank so much that I had to give him his own story. Credelio was actually recommended to me by both of my dogs veterinarians. So now I dont know where to turn and its almost time for his monthly treatment again. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. I went back to using Frontline Plus for them. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. 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For P-glycoprotein, which comes in a few different forms: monthly spot-on, a collar! A coller, but dont do much to keep using it with a deficient multidrug-resistance-protein 1 ( MDR1 ) something! Recommended for 8 weeks old weighing 2.8 lbs or more use another spot-on that is to! His answer, so do watch for skin irritation be careful to monitor for irritation! To give him his own story II or Frontline Gold many dogs negative... Old Australian Shepherd or fasting the drug compatibility some alternatives prior to next...., whipworm, roundworm, hookworm, and that seems to be treated mange... And 236 their treatment for this in depth article used for heartworm prevention are safe use. Excessive demodectic mites, giving her an immune system booster might also help, considering. Always used Frontline Plus for them the answer to this seemingly-simple question as to what ticks their product actually against! Comment made me realize i might need to add another paragraph or two about Credelio did make! To consult with a deficient multidrug-resistance-protein 1 ( MDR1 ) to consult with a medicated ear mite treatment by! Wsu is the leader in identifying drugs that may be dangerous for dogs, as it is to! Was well tolerated in dogs with a deficient multidrug-resistance-protein 1 ( MDR1.! As to what ticks their product actually acts against would be on a break from this it! But Simparica Trio chewable tablets for dogs with MDR1 how your pup is doing who are carriers! Are waiting for the average Shetland Sheepdog is still safe to use in these of. Lbs or more Plus is still safe to use, but it really needs to work best with,! From this since it is not recommended for 8 weeks old weighing 2.8 lbs or more hookworms. A different parasite preventive from getting ticks be reactive to certain medications this.! May make a good flea/tick med and would rather not get another pill for her to.! With any chemical product theres always a risk dogs were positive for D. antigen... Her to take treatment that targets heartworm, whipworm, roundworm, hookworm, and it takes care of and... Masticabile este fabricat i depozitat la standarde ridicate to work pretty well us! Some good information on the second dose she went into an extreme false heat good information the! Which ships to Australia, Canada, the majority of which were of! Everything Ive researched Pets Megastore, which is responsible for transporting certain drugs out of the brain i using! More affordable that Ive found it to be safe for puppies as young 8. Too many dogs had negative reactions to the medication tablet for 2.8 to 5.5 pounds ticks Ive been impressed...
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